+44 131 651 9675 info@roslintech.com

Partner Profile

Scaling up iPS cell lines for cultivated meat production

Cultivated meat has the ability to revolutionise the food industry – offering a sustainable way to produce meat that has the taste and texture of its traditional counterpart, whilst reducing the need for animals in process. In theory, cultivated meat production should be no different whether it is a 500 mL or 50 L bioreactor in use. However, in practice, what works on a small laboratory scale may not always translate well into larger scale general production.

Partner Profile

Scaling up iPS cell lines for cultivated meat production

Cultivated meat has the ability to revolutionise the food industry – offering a sustainable way to produce meat that has the taste and texture of its traditional counterpart, whilst reducing the need for animals in process. In theory, cultivated meat production should be no different whether it is a 500 mL or 50 L bioreactor in use. However, in practice, what works on a small laboratory scale may not always translate well into larger scale general production.

Image of a 5L bioreactor on a lab bench
Image of a 500mL beaker in an incubator

To tackle this challenge, Roslin Technologies has partnered with Dr Leo Rios-Solos, Lecturer in the University of Edinburgh’s School of Engineering. Our 1-year project has been awarded funding from the Industrial Biotechnology Innovation Centre (IBioIC), who support innovative ways to accelerate and de-risk the journey of bringing biotechnology solutions to market. Combining Roslin Tech’s induced pluripotent stem (iPS) cell lines and Dr Rios-Solos’ focus on bioprocess engineering will allow us to find new ways to sustainably scale up production of cultivated meat.

Industry need

For cultivated meat production, there is a clear need from the industry for a roadmap to sustainable and cost-effective scale up. While a lot of research has focused on the early stages of development – such as producing stable and relevant cell lines of interest – the interest is now turning to producing these cells on a large scale.

The project

Cultivated meat can transform how we consume meat in the future, but there is still a critical bottleneck to be overcome. Cost-effective scale up needs to be managed in order to produce consumer products that are similar in cost to regular meat products. From media costs to low cell growth in larger reactors, the challenges need to be understood and solutions found for the industry to move forward in their gastronomic revolution.

The project combines Roslin Tech’s unique animal induced pluripotent cell lines with Dr Rios-Solos’ bioprocess intensification methodologies to radically improve production. This project will offer real insight into how to close the scale-up gap which currently hinders cost-effective production.

Scientist fitting the lid of a 5L bioreactor
Porcine Bone derived from iPS cell lines

Addressing the challenges

Combining our iPS cell lines with Dr Rios-Solos’ expertise and research equipment offers the ability to conduct thousands of tests in smaller bioreactors, allowing for minor changes to be made to the conditions; from how cells are grown, to the media formulation used, and more. This will allow parameters to be optimised much faster than through traditional routes.

The first area of focus for the project will be on media formulation. We aim to find the optimum growth media at low cost, ensuring that it does not impact cellular growth. The ability to continually iterate minor changes in the cellular growth media allows for faster assessment and leads directly into our next research area.

The second key area of focus is a much larger undertaking – optimised scale-up for cellular production. Creating the optimum conditions is a relatively easy task in small bioreactors and producing small amounts of cultivated meat. However, when moving to the use of larger bioreactors for greater production output, more care is needed to ensure the conditions remain optimal.

Industry benefits

This project complements the cell lines on offer by Roslin Tech, and uniquely positions us in the market as an iPS cell line provider who has evidence and proven methods for scale-up cellular production.

The results from this project will be hugely important, helping to develop the food industry’s move towards sustainable protein production and development methods, as well as highlighting new ways to innovate and test methods for development.

We are excited to start this project in partnership with Dr Rios-Solos – keep up to date with how the project goes throughout the year.

IBioIC Innovation Fund

This project is funded through the IBioIC Innovation Fund. IBioIC is a networking and support organisation that connects industry, academia and government to bring biotechnology processes and products to the global market.

Visit their website to find out more: www.IBioIC.com

Find out more about our iPS cell lines on our dedicated pages

Read more

Porcine iPS cells differentiated into Adipocytes

IPS CELL LINES FOR CULTIVATED MEAT

Roslin Technologies has developed a novel method of iPS cell line creation. These cell lines can be used in cultivated meat production.

Piglets

Vaccine Delivery Vehicle: Parasite Engineering

As part of Roslin Tech’s drive to enhance sustainable protein production, we partner with academics conducting cutting-edge research that can have commercial impacts on the livestock industry.

Piglets

Gene Editing Shrimp: White Spot Syndrome Virus

As part of our drive for sustainable protein production, Roslin Technologies partner with academics working in key Scottish industries such as aquaculture.

Piglets

Genetic breeding programme for pigs

Danish Genetics represent Denmark’s leading pig breeders, producers and vendors who are working to provide a sustainable, welfare focussed system.

To tackle this challenge, Roslin Technologies has partnered with Dr Leo Rios-Solos, Lecturer in the University of Edinburgh’s School of Engineering. Our 1-year project has been awarded funding from the Industrial Biotechnology Innovation Centre (IBioIC), who support innovative ways to accelerate and de-risk the journey of bringing biotechnology solutions to market. Combining Roslin Tech’s induced pluripotent stem (iPS) cell lines and Dr Rios-Solos’ focus on bioprocess engineering will allow us to find new ways to sustainably scale up production of cultivated meat.

Image of a 500mL beaker in an incubator

Industry need

For cultivated meat production, there is a clear need from the industry for a roadmap to sustainable and cost-effective scale up. While a lot of research has focused on the early stages of development – such as producing stable and relevant cell lines of interest – the interest is now turning to producing these cells on a large scale.

The project

Cultivated meat can transform how we consume meat in the future, but there is still a critical bottleneck to be overcome. Cost-effective scale up needs to be managed in order to produce consumer products that are similar in cost to regular meat products. From media costs to low cell growth in larger reactors, the challenges need to be understood and solutions found for the industry to move forward in their gastronomic revolution.

The project combines Roslin Tech’s unique animal induced pluripotent cell lines with Dr Rios-Solos’ bioprocess intensification methodologies to radically improve production. This project will offer real insight into how to close the scale-up gap which currently hinders cost-effective production.

Scientist fitting the lid of a 5L bioreactor

Addressing the challenges

Combining our iPS cell lines with Dr Rios-Solos’ expertise and research equipment offers the ability to conduct thousands of tests in smaller bioreactors, allowing for minor changes to be made to the conditions; from how cells are grown, to the media formulation used, and more. This will allow parameters to be optimised much faster than through traditional routes.

The first area of focus for the project will be on media formulation. We aim to find the optimum growth media at low cost, ensuring that it does not impact cellular growth. The ability to continually iterate minor changes in the cellular growth media allows for faster assessment and leads directly into our next research area.

The second key area of focus is a much larger undertaking – optimised scale-up for cellular production. Creating the optimum conditions is a relatively easy task in small bioreactors and producing small amounts of cultivated meat. However, when moving to the use of larger bioreactors for greater production output, more care is needed to ensure the conditions remain optimal.

Porcine Bone derived from iPS cell lines

Industry benefits

This project complements the cell lines on offer by Roslin Tech, and uniquely positions us in the market as an iPS cell line provider who has evidence and proven methods for scale-up cellular production.

The results from this project will be hugely important, helping to develop the food industry’s move towards sustainable protein production and development methods, as well as highlighting new ways to innovate and test methods for development.

We are excited to start this project in partnership with Dr Rios-Solos – keep up to date with how the project goes throughout the year.

IBioIC Innovation Fund

This project is funded through the IBioIC Innovation Fund. IBioIC is a networking and support organisation that connects industry, academia and government to bring biotechnology processes and products to the global market.

Visit their website to find out more: www.IBioIC.com

Find out more about our iPS cell lines on our dedicated pages

Read more

Porcine iPS cells differentiated into Adipocytes

IPS CELL LINES FOR CULTIVATED MEAT

Roslin Technologies has developed a novel method of iPS cell line creation. These cell lines can be used in cultivated meat production.

Piglets

Vaccine Delivery Vehicle: Parasite Engineering

As part of Roslin Tech’s drive to enhance sustainable protein production, we partner with academics conducting cutting-edge research that can have commercial impacts on the livestock industry.

Piglets

Gene Editing Shrimp: White Spot Syndrome Virus

As part of our drive for sustainable protein production, Roslin Technologies partner with academics working in key Scottish industries such as aquaculture.

Piglets

Genetic breeding programme for pigs

Danish Genetics represent Denmark’s leading pig breeders, producers and vendors who are working to provide a sustainable, welfare focussed system.