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Case study

Vaccine Delivery Vehicle: Parasite Engineering

At Roslin Technologies, we focus on the science of sustainable protein production. 

For the traditional livestock industry, which is worth over $2 trillion1, diseases play a major role in reducing biological efficiency and sustainability of protein production for all types of livestock. This is a key concern for the sheep industry, which is currently estimated to be worth $14 billion2. The next decade is expected to see an increase of 14% in meat output from sheep farmers2 – however there are a wide range of diseases that can infect sheep and cattle. The industry is always on the lookout for treatments or novel vaccines that help to keep productivity high.

Case study

Vaccine Delivery Vehicle: Parasite Engineering

At Roslin Technologies, we focus on the science of sustainable protein production.

For the traditional livestock industry, which is worth over $2 trillion1, diseases play a major role in reducing biological efficiency and sustainability of protein production for all types of livestock. This is a key concern for the sheep industry, which is currently estimated to be worth $14 billion2. The next decade is expected to see an increase of 14% in meat output from sheep farmers2 – however there are a wide range of diseases that can infect sheep and cattle. The industry is always on the lookout for treatments or novel vaccines that help to keep productivity high.

Two piglets facing the camera
Sheep farming
Roslin Technologies Institute

Academic partnerships: from ideas to impacts

As part of our drive to enhance sustainable protein production, we partner with academics conducting cutting-edge research that can have commercial impacts on our key industries. We work closely with the University of Edinburgh’s School of Biological Sciences and Edinburgh Innovations’ Business Development team to leverage joint funding, combining their academic scientific rigour with our commercial priorities. 

Jointly supported by Roslin Tech and a BBSRC Impact Acceleration Account Award, Professor Keith Matthews, Professor of Parasite Biology and Dean of Bioscience Partnerships at the University of Edinburgh, is leading a project to develop a novel vaccine delivery platform to combat economically important pathogens of sheep and goats. 

This novel platform targets a highly infectious and potentially fatal disease – peste de petits ruminants virus (PPRV). PPRV threatens 80% of the global population of sheep and goats and is fatal in 50-70% of infections3. However, this innovative delivery vehicle can be tailored to express antigens from any target pathogen. 

This is the first time the vaccine delivery platform has been used in sheep, but it already has proven usage in cattle. It offers an alternative to traditional therapies which can often place an unnecessary burden on farmers by needing multiple applications. The vaccine vehicle has the ability to be a multi-type vaccine vehicle, with the future potential to deliver multiple vaccines for different diseases through its innovative technology. 

Commercial demand

Alongside the global meat market, the veterinary vaccine market is projected to reach $13 million by 20284. There is huge capacity in the sector for novel vaccines that can be applied and modified for diseases of interest, helping to increase biological efficiencies of herds and ensure sustainable protein production. 

While this project is focused on PPRV, the technology created by Prof. Matthews can be applied to other key disease targets in the future, limiting the burden on livestock owners through its single application to livestock. The data from our trials are promising, and the project is due to finish later in 2021.

 Find out more information on the vaccine delivery vehicle, and our other products and research projects in our portfolio.

1 IDTechEx
2 Ingentium Market Research
3 Science Daily
4 Allied Market Research

Learn more about our academic partnerships:

Read more

Porcine iPS cells differentiated into Adipocytes

IPS CELL LINES FOR CULTIVATED MEAT

Roslin Technologies has developed a novel method of iPS cell line creation. These cell lines can be used in cultivated meat production.

Piglets

Gene Editing Shrimp: White Spot Syndrome Virus

As part of our drive for sustainable protein production, Roslin Technologies partner with academics working in key Scottish industries such as aquaculture.

Piglets

Genetic breeding programme for pigs

Danish Genetics represent Denmark’s leading pig breeders, producers and vendors who are working to provide a sustainable, welfare focussed system.

Academic partnerships: from ideas to impacts 

As part of our drive to enhance sustainable protein production, we partner with academics conducting cutting-edge research that can have commercial impacts on our key industries. We work closely with the University of Edinburgh’s School of Biological Sciences and Edinburgh Innovations’ Business Development team to leverage joint funding, combining their academic scientific rigour with our commercial priorities. 

Jointly supported by Roslin Tech and a BBSRC Impact Acceleration Account Award, Professor Keith Matthews, Professor of Parasite Biology and Dean of Bioscience Partnerships at the University of Edinburgh, is leading a project to develop a novel vaccine delivery platform to combat economically important pathogens of sheep and goats. 

This novel platform targets a highly infectious and potentially fatal disease – peste de petits ruminants virus (PPRV). PPRV threatens 80% of the global population of sheep and goats and is fatal in 50-70% of infections3. However, this innovative delivery vehicle can be tailored to express antigens from any target pathogen. 

This is the first time the vaccine delivery platform has been used in sheep, but it already has proven usage in cattle. It offers an alternative to traditional therapies which can often place an unnecessary burden on farmers by needing multiple applications. The vaccine vehicle has the ability to be a multi-type vaccine vehicle, with the future potential to deliver multiple vaccines for different diseases through its innovative technology.

Porcine iPS cells differentiated into Adipocytes

Commercial demand

Alongside the global meat market, the veterinary vaccine market is projected to reach $13 million by 20284. There is huge capacity in the sector for novel vaccines that can be applied and modified for diseases of interest, helping to increase biological efficiencies of herds and ensure sustainable protein production.

While this project is focused on PPRV, the technology created by Prof. Matthews can be applied to other key disease targets in the future, limiting the burden on livestock owners through its single application to livestock. The data from our trials are promising, and the project is due to finish later in 2021.

Find out more information on the vaccine delivery vehicle project, and our other products and research projects in our portfolio.

1 IDTechEx
2 Ingentium Market Research
3 Science Daily
4 Allied Market Research

Sheep farming

Learn more about our academic partnerships:

Read more

Porcine iPS cells differentiated into Adipocytes

IPS CELL LINES FOR CULTIVATED MEAT

Roslin Technologies has developed a novel method of iPS cell line creation. These cell lines can be used in cultivated meat production.

Piglets

Gene Editing Shrimp: White Spot Syndrome Virus

As part of our drive for sustainable protein production, Roslin Technologies partner with academics working in key Scottish industries such as aquaculture.

Piglets

Genetic breeding programme for pigs

Danish Genetics represent Denmark’s leading pig breeders, producers and vendors who are working to provide a sustainable, welfare focussed system.